Translation of DNA signals into polymer assembly instructions

被引：141

作者：

Liao, SP ^{[1
]}

Seeman, NC ^{[1
]}

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

来源：

SCIENCE | 2004年 / 306卷 / 5704期

关键词：

D O I：

10.1126/science.1104299

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We developed a DNA nanomechanical device that enables the positional synthesis of products whose sequences are determined by the state of the device. This machine emulates the translational capabilities of the ribosome. The device has been prototyped to make specific DNA sequences. The state of the device is established by the addition of DNA set strands. There is no transcriptional relationship between the set strands and the product strands. The device has potential applications that include designer polymer synthesis, encryption of information, and use as a variable-input device for DNA-based computation.

引用

页码：2072 / 2074

页数：3

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