Highly Efficient Copper-Catalyzed Synthesis of Internal Alkynes via Aerobic Oxidative Arylation of Terminal Alkynes

被引：29

作者：

Rao, Honghua ^{[1
]}

Fu, Hua ^{[1
]}

Jiang, Yuyang ^{[1
,2
]}

Zhao, Yufen ^{[1
]}

机构：

[1] Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Dept Chem, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Kev Lab Chem Biol Guangdong Prov, Grad Sch Shenzhen, Shenzhen 518057, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 2-3期

基金：

中国国家自然科学基金;

关键词：

C-H activation; copper; internal alkynes; oxidative coupling; synthetic methods; CROSS-COUPLING REACTIONS; SONOGASHIRA REACTION; ARYLBORONIC ACIDS; FUNCTIONALIZATION; COMPLEXES;

D O I：

10.1002/adsc.200900723

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have developed a novel and highly efficient. copper-catalyzed synthesis of internal alkynes via oxidative couplings of aromatic horonic acids with terminal alkynes at room temperature. The protocol uses inexpensive copper(I) oxide [Cu2O] as the catalyst, oxygen in the air as the stoichiometric oxidant; no ligand and sealed reaction vessels are required, and remarkable functional group tolerability is observed with coupling occurring.

引用

页码：458 / 462

页数：5

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