Synthetic studies on apoptolidin: synthesis of the C12-C28 fragment via a highly stereoselective aldol reaction

被引：19

作者：

Abe, K ^{[1
]}

Kato, K ^{[1
]}

Arai, T ^{[1
]}

Rahim, MA ^{[1
]}

Sultana, I ^{[1
]}

Matsumura, S ^{[1
]}

Toshima, K ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 48期

基金：

日本学术振兴会;

关键词：

apoptolidin; macrolide; antibiotic; apoptosis; aldol reaction;

D O I：

10.1016/j.tetlet.2004.09.177

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective and convergent synthesis of the C12-C28 segment 2 of the apoptosis inducing macrolide antibiotic, apoptolidin (1), is described. The synthesis involves a highly stereoselective tin(II)-mediated aldol reaction between the C17-C22 ethyl ketone 3 and the C23-C28 aldehyde 4 as the key step. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8849 / 8853

页数：5

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