Differential hyperacetylation of histones H3 and H4 upon promoter-specific recruitment of EBNA2 in Epstein-Barr virus chromatin

被引：39

作者：

Alazard, N ^{[1
]}

Gruffat, H ^{[1
]}

Hiriart, E ^{[1
]}

Sergeant, A ^{[1
]}

Manet, E ^{[1
]}

机构：

[1] Ecole Normale Super Lyon, INSERM U412, Unite Virol Humaine, F-69364 Lyon 07, France

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 14期

关键词：

D O I：

10.1128/JVI.77.14.8166-8172.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epstein-Barr virus nuclear antigen 2 (EBNA2) is a transcriptional activator involved in the immortalization of B lymphocytes by the virus. EBNA2 is targeted to the promoters of its responsive genes, via interaction with cellular DNA-binding proteins. Using chromatin immunoprecipitation assays, we show for the first time the conditional recruitment of EBNA2 on two specific viral promoters in vivo and demonstrate a correlation between this recruitment and a local change in the acetylation of histones H3 and H4, which is promoter dependent.

引用

页码：8166 / 8172

页数：7

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