Total synthesis of mycophenolic acid

被引：26

作者：

Covarrubias-Zúñiga, A ^{[1
]}

Gonzalez-Lucas, A ^{[1
]}

Domínguez, MM ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

来源：

TETRAHEDRON | 2003年 / 59卷 / 11期

关键词：

mycophenolic acid; Michael addition; Dieckmann condensation;

D O I：

10.1016/S0040-4020(03)00102-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent total synthesis of the natural compound mycophenolic acid 1 is described. The synthetic strategy for the construction of the hexasubstituted aromatic nucleus was based on a ring annulation sequence, involving a Michael addition reaction and intramolecular Dieckmann condensation reaction in situ as the key step. Subsequent transformations of the substituents afforded the target mycophenolic acid 1. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1989 / 1994

页数：6

共 31 条

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