The MSL complex: X chromosome and beyond

被引：21

作者：

Laverty, Corey ^{[1
]}

Lucci, Jacopo ^{[1
,2
]}

Akhtar, Asifa ^{[1
]}

机构：

[1] Max Planck Inst Immunobiol, D-79108 Freiburg, Germany

[2] EMBL, Heidelberg, Germany

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 02期

关键词：

DOSAGE COMPENSATION COMPLEX; CHROMATIN REMODELING COMPLEX; DEPENDENT GENE-REGULATION; ACETYLATES HISTONE H4; DROSOPHILA-MELANOGASTER; BIDIRECTIONAL PROMOTERS; H4-K16; ACETYLATION; ANALYSIS REVEALS; LETHAL COMPLEX; LYSINE; 16;

D O I：

10.1016/j.gde.2010.01.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

X chromosomal regulation is a process that presents systematic problems of chromosome recognition and coordinated gene regulation. In Drosophila males, the ribonucleoprotein Male-Specific Lethal (MSL) complex plays an important role in hyperactivation of the X-linked genes to equalize gene dosage differences between the sexes. It appears that X chromosome recognition by the MSL complex may be mediated through a combination of sequence-specificity and transcriptional activities. The resulting transcriptional up-regulation also seems to involve several mechanisms, encompassing both gene-specific and chromosome-wide approaches. Interestingly the histone H4 lysine 16 specific MOF histone acetyl transferase, a key MSL member that hyper-acetylates the male X chromosome, is also involved in gene regulation beyond dosage compensation. A comparison of Drosophila and mammalian systems reveals intriguing parallels in MOF behavior, and highlights the multidisciplinary nature of this enzyme.

引用

页码：171 / 178

页数：8

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