Demystified ... Human endogenous retroviruses

被引：139

作者：

Nelson, PN

Carnegie, PR

Martin, J

Ejtehadi, HD

Hooley, P

Roden, D

Rowland-Jones, S

Warren, P

Astley, J

Murray, PG

机构：

[1] Wolverhampton Univ, Sch Appl Sci, Mol Immunol Labs, Div Biomed Sci & Biosci, Wolverhampton WV1 1SB, England

[2] Univ Western Australia, Ctr Mol Immunol & Instrumentat, Perth, WA 6152, Australia

[3] John Radcliffe Hosp, Oxford OX3 9DU, England

[4] Univ Birmingham, Dept Pathol, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 2003年 / 56卷 / 01期

关键词：

D O I：

10.1136/mp.56.1.11

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.

引用

页码：11 / 18

页数：8

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