There's NO stopping NsrR, a global regulator of the bacterial NO stress response

被引：103

作者：

Tucker, Nicholas P. ^{[1
]}

Le Brun, Nick E. ^{[2
]}

Dixon, Ray ^{[3
]}

Hutchings, Matthew I. ^{[4
,5
]}

机构：

[1] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Royal Coll, Glasgow GR1 1XW, Lanark, Scotland

[2] Univ E Anglia, Sch Chem, Norwich NR4 7TJ, Norfolk, England

[3] John Innes Ctr, Dept Mol Microbiol, Norwich NR4 7UH, Norfolk, England

[4] Univ E Anglia, Sch Biol Sci, Norwich NR4 7TJ, Norfolk, England

[5] Univ E Anglia, Sch Med Hlth Policy & Practice, Norwich NR4 7TJ, Norfolk, England

来源：

TRENDS IN MICROBIOLOGY | 2010年 / 18卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

HYBRID CLUSTER PROTEIN; SENSITIVE TRANSCRIPTIONAL REGULATOR; TRUNCATED DENITRIFICATION PATHWAY; ENTERICA SEROVAR TYPHIMURIUM; ESCHERICHIA-COLI K-12; SENSES NITRIC-OXIDE; NONHEME IRON CENTER; NEISSERIA-MENINGITIDIS; NITROSATIVE STRESS; BACILLUS-SUBTILIS;

D O I：

10.1016/j.tim.2009.12.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) is a toxic, free radical gas with diverse biological roles in eukaryotes and bacteria, being involved in signalling, vasodilation, blood clotting and immunity and as an intermediate in microbial denitrification. Several bacterial transcriptional regulators sense this molecule and regulate the expression of genes involved in both NO detoxification and NO damage repair. However, a recently discovered NO sensing repressor, named NsrR, has gained attention because of its suggested role as a global regulator of the bacterial NO stress response. Recent advances in biochemical and transcriptomic studies of NsrR make it timely to review the current evidence for NsrR as a global regulator and to speculate on the recent controversy over its NO sensing mechanism.

引用

页码：149 / 156

页数：8

共 65 条

[31] New genes implicated in the protection of anaerobically grown Escherichia coli against nitric oxide [J].

Justino, MC ;

Vicente, JB ;

Teixeira, M ;

Saraiva, LM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (04) :2636-2643

[32] Deletion of two downstream genes alters expression of the hmc operon of Desulfovibrio vulgaris subsp. vulgaris Hildenborough [J].

Keon, RG ;

Fu, RD ;

Voordouw, G .

ARCHIVES OF MICROBIOLOGY, 1997, 167 (06) :376-383

[33] Anoxic function for the Escherichia coli flavohaemoglobin (Hmp):: reversible binding of nitric oxide and reduction to nitrous oxide [J].

Kim, SO ;

Orii, Y ;

Lloyd, D ;

Hughes, MN ;

Poole, RK .

FEBS LETTERS, 1999, 445 (2-3) :389-394

[34] Site-directed mutagenesis of NnrR:: a transcriptional regulator of nitrite and nitric oxide reductase in Rhodobacter sphaeroides [J].

Laratta, WP ;

Shapleigh, JP .

FEMS MICROBIOLOGY LETTERS, 2003, 229 (02) :173-178

[35] Activation of yeaR-yoaG operon transcription by the Nitrate-responsive regulator NarL is independent of oxygen responsive regulator fnr in Escherichia coli K-12 [J].

Lin, Hsia-Yin ;

Bledsoe, Peggy J. ;

Stewart, Valley .

JOURNAL OF BACTERIOLOGY, 2007, 189 (21) :7539-7548

[36] Nitric oxide and macrophage function [J].

MacMicking, J ;

Xie, QW ;

Nathan, C .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :323-350

[37] Prominent roles of the NorR and Fur regulators in the Escherichia coli transcriptional response to reactive nitrogen species [J].

Mukhopadhyay, P ;

Zheng, M ;

Bedzyk, LA ;

LaRossa, RA ;

Storz, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (03) :745-750

[38] The hypersensitive response; the centenary is upon us but how much do we know? [J].

Mur, Luis A. J. ;

Kenton, Paul ;

Lloyd, Amanda J. ;

Ougham, Helen ;

Prats, Elena .

JOURNAL OF EXPERIMENTAL BOTANY, 2008, 59 (03) :501-520

[39] Induction of ResDE-dependent gene expression in Bacillus subtilis in response to nitric oxide and nitrosative stress [J].

Nakano, MM .

JOURNAL OF BACTERIOLOGY, 2002, 184 (06) :1783-1787

[40] Sequence-Specific Binding to a Subset of IscR-Regulated Promoters Does Not Require IscR Fe-S Cluster Ligation [J].

Nesbit, A. D. ;

Giel, J. L. ;

Rose, J. C. ;

Kiley, P. J. .

JOURNAL OF MOLECULAR BIOLOGY, 2009, 387 (01) :28-41

← 1 2 3 4 5 6 7 →