Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors

被引:290
作者
Rechsteiner, M [1 ]
Hill, CP [1 ]
机构
[1] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84132 USA
关键词
D O I
10.1016/j.tcb.2004.11.003
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Proteasomes perform the majority of proteolysis that occurs in the cytosol and nucleus of eukaryotic cells and, thereby, perform crucial roles in cellular regulation and homeostasis. Isolated proteasomes are inactive because substrates cannot access the proteolytic sites. PA28 and PA200 are activators that bind to proteasomes and stimulate the hydrolysis of peptides. Several protein inhibitors of the proteasome have also been identified, and the properties of these activators and inhibitors have been characterized biochemically. By contrast, their physiological roles - which have been reported to include production of antigenic peptides, proteasome assembly and DNA repair - are controversial. In this article, we briefly review the biochemical data and discuss the possible biological roles of PA28, PA200 and proteasome inhibitors.
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收藏
页码:27 / 33
页数:7
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