Macrophages and the hypoxic tumour microenvironment

被引：55

作者：

Knowles, Helen J.

Harris, Adrian L. ^{[1
]}

机构：

[1] Johns Hopkins Univ Hosp, Weatherall Inst Mol Med, Canc Res UK, Oxford OX3 7NG, England

[2] Univ Oxford, Botnar Res Ctr, Nuffield Dept Orthopaed Surg, Oxford OX3 7LD, England

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2007年 / 12卷

关键词：

tumour-associated macrophage; TAM; angiogenesis; hypoxia; immunosuppression; migration; metastasis; therapy; review;

D O I：

10.2741/2389

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One characteristic of solid tumour tissue is the presence of large numbers of tumour-associated macrophages. These migrate down gradients of chemo-attractive agents to accumulate within hypoxic and / or necrotic areas where they are generally related to poor clinical prognosis. In this review we will discuss the molecular mechanisms that underlie recruitment of macrophages into tumours and their pro- tumourigenic activities with respect to stimulation of angiogenesis, lymphangiogenesis, tumour cell migration, metastasis and immuno- suppression. The potential of macrophage- related anticancer therapies will be discussed in the light of this phenotype.

引用

收藏

页码：4298 / 4314

页数：17

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