A novel stereoselective access to substituted L-2-deoxypentono-1,4-lactones and 1-2-deoxypentoses

被引:9
作者
Johnson, DV [1 ]
Fischer, R [1 ]
Griengl, H [1 ]
机构
[1] Graz Tech Univ, Inst Organ Chem, Spezialforsch Bereich Biokatalyse, A-8010 Graz, Austria
关键词
hydroxynitrile lyase; tartaric acid; cyanohydrin; L-2-deoxypentoses;
D O I
10.1016/S0040-4020(00)00871-1
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A stereoselective method to L-2-deoxypentose or L-2-deoxy-pentono-1,4-lactone units was developed employing the (S)-Hydroxynitrile lyase from Hevea brasiliensis. Additionally a diastereoselective reduction using either (D)- or (L)-tartaric acid in conjuction with sodium borohydride had been applied to control the ultimate stereochemistry of the bioactive compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:9289 / 9295
页数:7
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