Structural biology of RNA silencing and its functional implications

被引：26

作者：

Patel, D. J.

Ma, J.-B.

Ye, K.

Pei, Y.

Kuryavyi, V.

Malinina, L.

Meister, G.

Tuschl, T.

机构：

[1] Mem Sloan Kettering Canc Ctr, Struct Biol Program, New York, NY 10021 USA

[2] Rockefeller Univ, Lab RNA Biol, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY | 2006年 / 71卷

关键词：

D O I：

10.1101/sqb.2006.71.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We outline structure-function contributions front our laboratories on protein-RNA recognition events that monitor siRNA length, 5'-phosphale and 2-nucleotide 3' overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release.

引用

收藏

页码：81 / 93

页数：13

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