Structural domains in RNAi

被引：59

作者：

Collins, RE

Cheng, XD

机构：

[1] Emory Univ, Dept Biochem, Atlanta, GA 30322 USA

[2] Emory Univ, Grad Program Biochem Cell & Dev Biol, Atlanta, GA 30322 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 26期

关键词：

PAZ; PIWI; argonaute; dsRBD; RNaseIII;

D O I：

10.1016/j.febslet.2005.07.072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double-stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two related functions, highlighting models of Drosha, Dicer, and RISC function. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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收藏

页码：5841 / 5849

页数：9

相关论文

共 52 条

[1] RNA silencing and genome regulation [J].

Almeida, R ;

Allshire, RC .

TRENDS IN CELL BIOLOGY, 2005, 15 (05) :251-258

[2] Noncatalytic assembly of ribonuclease III with double-stranded RNA [J].

Blaszczyk, J ;

Gan, JH ;

Tropea, JE ;

Court, DL ;

Waugh, DS ;

Ji, XH .

STRUCTURE, 2004, 12 (03) :457-466

[3] Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage [J].

Blaszczyk, J ;

Tropea, JE ;

Bubunenko, M ;

Routzahn, KM ;

Waugh, DS ;

Court, DL ;

Ji, XH .

STRUCTURE, 2001, 9 (12) :1225-1236

[4] Recognition of double-stranded RNA by proteins and small molecules [J].

Carlson, CB ;

Stephens, OM ;

Beal, PA .

BIOPOLYMERS, 2003, 70 (01) :86-102

[5] RNase III enzymes and the initiation of gene silencing [J].

Carmell, MA ;

Hannon, GJ .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (03) :214-218

[6] A novel RNA-binding motif in influenza A virus non-structural protein 1 [J].

Chien, CY ;

Tejero, R ;

Huang, YP ;

Zimmerman, DE ;

Rios, CB ;

Krug, RM ;

Montelione, GT .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (11) :891-895

[7]

Delano WL., 2002, The PyMOL Molecular Graphics System

[8] The Microprocessor complex mediates the genesis of microRNAs [J].

Gregory, RI ;

Yan, KP ;

Amuthan, G ;

Chendrimada, T ;

Doratotaj, B ;

Cooch, N ;

Shiekhattar, R .

NATURE, 2004, 432 (7014) :235-240

[9] Kinetic analysis of the RNAi enzyme complex [J].

Haley, B ;

Zamore, PD .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (07) :599-606

[10] Two classes of short interfering RNA in RNA silencing [J].

Hamilton, A ;

Voinnet, O ;

Chappell, L ;

Baulcombe, D .

EMBO JOURNAL, 2002, 21 (17) :4671-4679

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