CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells

被引:41
作者
Hasegawa, Masaki
Hagiwara, Sumitaka
Sato, Tomoko
Jijiwa, Mayumi
Murakumo, Yoshiki
Maeda, Masahiro
Moritani, Suzuko
Ichihara, Shu
Takahashi, Masahide
机构
[1] Nagoya Univ, Grad Sch Med, Dept Pathol, Showa Ku, Nagoya, Aichi 4668550, Japan
[2] Nagoya Univ, Grad Sch Med, Dept Oral & Maxillofacial Surg, Showa Ku, Nagoya, Aichi 4668550, Japan
[3] Natl Hosp Org, Nagoya Med Ctr, Dept Pathol, Nagoya, Aichi, Japan
[4] Nagoya Univ, Grad Sch Med, Ctr Neurol Dis & Canc, Div Mol Pathol, Nagoya, Aichi, Japan
[5] Immunobiol Lab, Fujioka, Japan
关键词
basal cells; CD109; immunohistochemistry; lacrimal gland; mammary gland; myoepithelial cells; prostate; salivary gland;
D O I
10.1111/j.1440-1827.2007.02097.x
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The CD109 gene encodes a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. Herein it is shown that CD109 is highly expressed in myoepithelial cells of mammary, salivary, and lacrimal glands; and in prostate basal cells. The anti-CD109 antibody generated by the authors was available for formalin-fixed paraffin section, and it strongly stained myoepithelial cells and basal cells but not ductal, acinar, and secretory cells in these glands. CD109 expression was negative in examined breast ductal carcinomas and prostate adenocarcinomas. These findings indicate that CD109 is a useful marker for the diagnosis of invasive breast and prostate carcinomas.
引用
收藏
页码:245 / 250
页数:6
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