PRDM9 points the zinc finger at meiotic recombination hotspots

被引：19

作者：

Neale, Matthew J. ^{[1
]}

机构：

[1] Univ Sussex, MRC, Genome Damage & Stabil Ctr, Brighton BN1 9RQ, E Sussex, England

来源：

GENOME BIOLOGY | 2010年 / 11卷 / 02期

基金：

英国医学研究理事会;

关键词：

INITIATION;

D O I：

10.1186/gb-2010-11-2-104

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Meiotic recombination events are spread nonrandomly across eukaryotic genomes in 'hotspots'. Recent work shows that a unique histone methyltransferase, PRDM9, determines their distribution.

引用

页数：3

共 11 条

[1] PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice [J].

Baudat, F. ;

Buard, J. ;

Grey, C. ;

Fledel-Alon, A. ;

Ober, C. ;

Przeworski, M. ;

Coop, G. ;

de Massy, B. .

SCIENCE, 2010, 327 (5967) :836-840

[2] Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites [J].

Borde, Valerie ;

Robine, Nicolas ;

Lin, Waka ;

Bonfils, Sandrine ;

Geli, Vincent ;

Nicolas, Alain .

EMBO JOURNAL, 2009, 28 (02) :99-111

[3] Distinct histone modifications define initiation and repair of meiotic recombination in the mouse [J].

Buard, Jerome ;

Barthes, Pauline ;

Grey, Corinne ;

de Massy, Bernard .

EMBO JOURNAL, 2009, 28 (17) :2616-2624

[4] A histone H3 methyltransferase controls epigenetic events required for meiotic prophase [J].

Hayashi, K ;

Yoshida, K ;

Matsui, Y .

NATURE, 2005, 438 (7066) :374-378

[5] Where the crossovers are: Recombination distributions in mammals [J].

Kauppi, L ;

Jeffreys, AJ ;

Keeney, S .

NATURE REVIEWS GENETICS, 2004, 5 (06) :413-424

[6] A fine-scale map of recombination rates and hotspots across the human genome [J].

Myers, S ;

Bottolo, L ;

Freeman, C ;

McVean, G ;

Donnelly, P .

SCIENCE, 2005, 310 (5746) :321-324

[7] A common sequence motif associated with recombination hot spots and genome instability in humans [J].

Myers, Simon ;

Freeman, Colin ;

Auton, Adam ;

Donnelly, Peter ;

McVean, Gil .

NATURE GENETICS, 2008, 40 (09) :1124-1129

[8] Accelerated Evolution of the Prdm9 Speciation Gene across Diverse Metazoan Taxa [J].

Oliver, Peter L. ;

Goodstadt, Leo ;

Bayes, Joshua J. ;

Birtle, Zoe ;

Roach, Kevin C. ;

Phadnis, Nitin ;

Beatson, Scott A. ;

Lunter, Gerton ;

Malik, Harmit S. ;

Ponting, Chris P. .

PLOS GENETICS, 2009, 5 (12)

[9] Prdm9 Controls Activation of Mammalian Recombination Hotspots [J].

Parvanov, Emil D. ;

Petkov, Petko M. ;

Paigen, Kenneth .

SCIENCE, 2010, 327 (5967) :835-835

[10] Probing meiotic recombination decisions [J].

Roig, Ignasi ;

Keeney, Scott .

DEVELOPMENTAL CELL, 2008, 15 (03) :331-332

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