Microcantilever-based platforms as biosensing tools

被引:131
作者
Alvarez, Mar
Lechuga, Laura M. [1 ]
机构
[1] CIN2 CSIC ICN, Nanobiosensors & Bioanalyt Applicat Grp, Res Ctr Nanosci & Nanotechnol, Bellaterra 08193, Spain
关键词
PROSTATE-SPECIFIC ANTIGEN; SELF-ASSEMBLED MONOLAYERS; QUARTZ-CRYSTAL MICROBALANCE; CANTILEVER ARRAY SENSORS; LABEL-FREE DETECTION; SURFACE STRESS; NANOMECHANICAL BIOSENSORS; CONFORMATIONAL-CHANGE; RECEPTOR MOLECULES; DNA HYBRIDIZATION;
D O I
10.1039/b908503n
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The fast and progressive growth of the biotechnology and pharmaceutical fields forces the development of new and powerful sensing techniques for process optimization and detection of biomolecules at very low concentrations. During the last years, the simplest MEMS structures, i.e. microcantilevers, have become an emerging and promising technology for biosensing applications, due to their small size, fast response, high sensitivity and their compatible integration into "lab-on-a-chip'' devices. This article provides an overview of some of the most interesting bio-detections carried out during the last 2-3 years with the microcantilever-based platforms, which highlight the continuous expansion of this kind of sensor in the medical diagnosis field, reaching limits of detection at the single molecule level.
引用
收藏
页码:827 / 836
页数:10
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