In vivo NMR and MRI using injection delivery of laser-polarized xenon

被引：62

作者：

Goodson, BM

Song, YQ

Taylor, RE

Schepkin, VD

Brennan, KM

Chingas, GC

Budinger, TF

Navon, G

Pines, A

机构：

[1] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

[4] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 26期

关键词：

xenon injection; optical pumping;

D O I：

10.1073/pnas.94.26.14725

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-lattice relaxation times and relatively low concentrations of xenon attainable in the body. Preliminary results from the application of a polarized xenon injection technique for in vivo Xe-129 NMR/MRI are extrapolated along with a simple model of xenon transit to show that the peak local concentration of polarized xenon delivered to tissues by injection may exceed that delivered by respiration by severalfold.

引用

页码：14725 / 14729

页数：5

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