Diisopropylamide and TMP Turbo-Grignard Reagents: A Structural Rationale for their Contrasting Reactivities

被引：71

作者：

Armstrong, David R. ^{[1
]}

Garcia-Alvarez, Pablo ^{[1
]}

Kennedy, Alan R. ^{[1
]}

Mulvey, Robert E. ^{[1
]}

Parkinson, John A. ^{[1
]}

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 18期

基金：

英国工程与自然科学研究理事会;

关键词：

amides; DOSY NMR spectroscopy; Grignard reagents; metalation; structure elucidation; CHEMOSELECTIVE MULTIPLE FUNCTIONALIZATION; ALKALI-METAL-MAGNESIUM; BR/MG EXCHANGE; NMR; LICL; MAGNESIATIONS; SPECTROSCOPY; CHEMISTRY; ARENES;

D O I：

10.1002/anie.201000539

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Turbocharged! A neutral dimeric molecule in crystal form, the diisopropylamido turbo-Grignard reagent "(iPr2N) MgCI· LiCl" (see structure; blue N, red O, green Mg, yellow Cl, black C) separates into several charged ate species in dynamic exchange with each other in THF solution as determined by a combination of EXSY and DOSY NMR studies. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3185 / 3188

页数：4

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