Matrix metalloproteinases as valid clinical targets

被引:200
作者
Fingleton, Barbara [1 ]
机构
[1] Vanderbilt Univ, Ctr Med, Dept Canc Biol, Nashville, TN USA
关键词
inflammation; remodeling; acute therapy; topical; cardiovascular disease;
D O I
10.2174/138161207779313551
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The matrix metalloproteinase family of enzymes has been a pharmaceutical target for over 20 years. In that time, many drugs have been developed but none have successfully passed clinical trials. A significant problem has been development of dose-limiting side-effects that were revealed during long-term clinical trials in diseases such as arthritis and various cancers. There are, however, other clinical settings where evidence for MMP function contributing to the pathophysiology of disease is strong. A number of these settings will be discussed here together with evidence from animal models that MMP inhibition is a valid strategy to be considered. A major advantage with many of these settings is that drug exposure may not have to be long-term and/or systemic thus reducing the possibility that side-effects will stymie MMPI-based therapy.
引用
收藏
页码:333 / 346
页数:14
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