Serum granulocyte colony-stimulating factor levels are not increased in patients with autoimmune neutropenia of infancy

被引:9
作者
Corbacioglu, S
Bux, J
König, A
Gabrilove, JL
Welte, K
Bussel, JB
机构
[1] New York Hosp, Dept Pediat, Div Hematol Oncol, New York, NY 10021 USA
[2] Cornell Univ Med Coll, New York, NY USA
[3] Univ Giessen, Inst Clin Immunol & Transfus Med, D-6300 Giessen, Germany
[4] Mt Sinai Med Ctr, Donald H Rattenberg Canc Ctr, New York, NY 10029 USA
[5] Hannover Med Sch, Dept Pediat Hematol & Oncol, D-3000 Hannover, Germany
关键词
D O I
10.1067/mpd.2000.106564
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: To assess the role of granulocyte colony-stimulating factor (G-CSF in autoimmune neutropenia (AIN). Design: Serum G-CSF levels were measured in 57 children with AlN. Two different G-CSF-dependent assays were used: a solid-phase "sandwich" enzyme-linked immunosorbent assay and a proliferation assay. Sera from healthy persons and from patients with severe congenital neutropenia were used for negative and positive controls. Results: The median G-CSF level in healthy persons (n = 13) was low, 45.6 pg/mL (range <39 to 141 pg/mL). The median G-CSF level;n patients with AIN (n = 57) was very similar, 45.5 pg/mL, (range <39 to 2500 pg/mL). Forty-five (79%) of 57 patients with AIN had levels within the range of the control group. Seven (12%) had marginally increased G-CSF levels (141 to 400 pg/mL), and only 5 (9%) had levels higher than 400 pg/mL. The G-CSF levels measured by enzyme-linked immunosorbent assay correlated well with levels measured by the proliferation assay, thus demonstrating that antibodies present in patient sera did not affect the biologic activity of C-CSF. Conclusion: G-CSF production in AIN is not;increased despite the low neutrophil count, similar to thrombopoietin in immune thrombocytopenic purpura.
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页码:96 / 99
页数:4
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