Nano/Microfluidics for diagnosis of infectious diseases in developing countries

被引:265
作者
Lee, Won Gu [1 ,2 ]
Kim, Yun-Gon [1 ,2 ,3 ]
Chung, Bong Geun [1 ,2 ]
Demirci, Utkan [1 ,2 ,3 ]
Khademhosseini, Ali [1 ,2 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Biomed Engn,Dept Med, Cambridge, MA 02139 USA
[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[3] Harvard Univ, Sch Med, Brigham & Womens Hosp, BAMM Lab, Cambridge, MA 02139 USA
关键词
Nano/Microfluidics; Infectious diseases; HIV/AIDS; Point-of-care; Diagnostics; Global health; OF-CARE DIAGNOSTICS; ON-A-CHIP; RESOURCE-POOR SETTINGS; ATOMIC-FORCE MICROSCOPY; TOTAL ANALYSIS SYSTEMS; CLINICAL DIAGNOSTICS; GLOBAL HEALTH; MICROFLUIDIC TECHNOLOGIES; FLOW CHROMATOGRAPHY; DEVELOPING-WORLD;
D O I
10.1016/j.addr.2009.11.016
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nano/Microfluidic technologies are emerging as powerful enabling tools for diagnosis and monitoring of infectious diseases in both developed and developing countries. Miniaturized nano/microfluidic platforms that precisely manipulate small fluid volumes can be used to enable medical diagnosis in a more rapid and accurate manner. In particular, these nano/microfluidic diagnostic technologies are potentially applicable to global health applications, since they are disposable, inexpensive, portable, and easy-to-use for detection of infectious diseases. In this paper, we review recent advances in nano/microfluidic technologies for clinical point-of-care applications at resource-limited settings in developing countries. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:449 / 457
页数:9
相关论文
共 97 条
[1]   Rapid automated cell quantification on HIV microfluidic devices [J].
Alyassin, Mohamad A. ;
Moon, SangJun ;
Keles, Hasan O. ;
Manzur, Fahim ;
Lin, Richard L. ;
Haeggstrom, Edward ;
Kuritzkes, Daniel R. ;
Demirci, Utkan .
LAB ON A CHIP, 2009, 9 (23) :3364-3369
[2]   Microfluidic modeling of cell-cell interactions in malaria pathogenesis [J].
Antia, Meher ;
Herricks, Thurston ;
Rathod, Pradipsinh K. .
PLOS PATHOGENS, 2007, 3 (07) :939-948
[3]   Expansion channel for microchip flow cytometers [J].
Bang, Hyunwoo ;
Yun, Hoyoung ;
Lee, Won Gu ;
Park, Junha ;
Lee, Jooruno ;
Chung, Seok ;
Cho, Keunchang ;
Chung, Chanil ;
Han, Dong-Chul ;
Chang, Jun Kenn .
LAB ON A CHIP, 2006, 6 (10) :1381-1383
[4]   Ensuring quality and access for malaria diagnosis: how can it be achieved? [J].
Bell, David ;
Wongsrichanalai, Chansuda ;
Barnwell, John W. .
NATURE REVIEWS MICROBIOLOGY, 2006, 4 (09) :682-695
[5]   Design and testing of a disposable microfluidic chemiluminescent immunoassay for disease biomarkers in human serum samples [J].
Bhattacharyya, A. ;
Klapperich, C. M. .
BIOMEDICAL MICRODEVICES, 2007, 9 (02) :245-251
[6]   Mobile Phone Based Clinical Microscopy for Global Health Applications [J].
Breslauer, David N. ;
Maamari, Robi N. ;
Switz, Neil A. ;
Lam, Wilbur A. ;
Fletcher, Daniel A. .
PLOS ONE, 2009, 4 (07)
[7]   Weighing of biomolecules, single cells and single nanoparticles in fluid [J].
Burg, Thomas P. ;
Godin, Michel ;
Knudsen, Scott M. ;
Shen, Wenjiang ;
Carlson, Greg ;
Foster, John S. ;
Babcock, Ken ;
Manalis, Scott R. .
NATURE, 2007, 446 (7139) :1066-1069
[8]  
Butte MJ, 2005, CLIN IMMUNOL, V116, P282
[9]   Lateral flow microarrays: a novel platform for rapid nucleic acid detection based on miniaturized lateral flow chromatography [J].
Carter, Darren J. ;
Cary, R. Bruce .
NUCLEIC ACIDS RESEARCH, 2007, 35 (10)
[10]  
Cheng XH, 2007, JAIDS-J ACQ IMM DEF, V45, P257