Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation

被引：40

作者：

Hu, Yueshan ^{[1
]}

Fahmy, Hesham ^{[1
]}

Zjawiony, Jordan K. ^{[2
,3
]}

Davies, Gareth E. ^{[1
,4
,5
]}

机构：

[1] S Dakota State Univ, Dept Pharmaceut Sci, Coll Pharm, Brookings, SD 57007 USA

[2] Univ Mississippi, Sch Pharm, Pharmaceut Sci Res Inst, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[4] Avera Behav Hlth Ctr, Avera Inst Human Behav Genet, Sioux Falls, SD 57108 USA

[5] Univ S Dakota, Dept Psychiat, Sanford Sch Med, Vermillion, SD 57069 USA

来源：

FITOTERAPIA | 2010年 / 81卷 / 04期

关键词：

Berberine; Evodiamine; Combination; Human white preadipocyte; Differentiation; GATA; ACTIVATED PROTEIN-KINASE; IN-VITRO; ADIPOCYTE DIFFERENTIATION; MECHANISM DISTINCT; SUPPRESSION; OBESITY; GAMMA; GATA;

D O I：

10.1016/j.fitote.2009.09.012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

It has been reported that the botanical alkaloids, berberine and evodiamine inhibit mouse preadipocyte 3T3-L1 differentiation. The aim of this study was to investigate the effect and transcriptional impact of berberine and evodiamine individually and in combination on human white preadipocyte (HWP) differentiation. We have shown that treatment with 8 mu M berberine or 4 mu M evodiamine resulted in a major inhibition of HWP differentiation accompanied by up-regulation of both GATA binding protein 2 and 3 (GATA-2 and GATA-3) mRNA and protein expression, suggesting that both compounds may have excellent potential as agents to prevent obesity. (C) 2009 Elsevier BM. All rights reserved.

引用

页码：259 / 268

页数：10

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