Circulating 25-Hydroxyvitamin D and Risk of Kidney Cancer

被引：36

作者：

Gallicchio, Lisa ^{[1
,2
]}

Moore, Lee E. ^{[4
]}

Stevens, Victoria L. ^{[3
]}

Ahn, Jiyoung ^{[5
,6
]}

Albanes, Demetrius ^{[4
]}

Hartmuller, Virginia ^{[7
]}

Setiawan, V. Wendy ^{[8
]}

Helzlsouer, Kathy J. ^{[1
,2
]}

Yang, Gong ^{[9
]}

Xiang, Yong-Bing ^{[10
]}

Shu, Xiao-Ou ^{[9
]}

Snyder, Kirk ^{[11
]}

Weinstein, Stephanie J. ^{[4
]}

Yu, Kai ^{[4
]}

Zeleniuch-Jacquotte, Anne ^{[5
,6
]}

Zheng, Wei ^{[9
]}

Cai, Qiuyin ^{[9
]}

Campbell, David S. ^{[11
]}

Chen, Yu ^{[5
,6
]}

Chow, Wong-Ho ^{[4
]}

Horst, Ronald L. ^{[12
]}

Kolonel, Laurence N. ^{[13
]}

McCullough, Marjorie L. ^{[3
]}

Purdue, Mark P. ^{[4
]}

Koenig, Karen L. ^{[5
]}

机构：

[1] Mercy Med Ctr, Weinberg Ctr Womens Hlth & Med, Prevent & Res Ctr, Baltimore, MD 21202 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[4] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[5] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[6] NYU, Inst Canc, New York, NY USA

[7] Sci Consulting Grp Inc, Gaithersburg, MD USA

[8] Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90033 USA

[9] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Dept Med,Div Epidemiol, Nashville, TN 37212 USA

[10] Shanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China

[11] Informat Management Serv Inc, Silver Spring, MD USA

[12] Heartland Assays Inc, Ames, IA USA

[13] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2010年 / 172卷 / 01期

基金：

美国国家卫生研究院;

关键词：

case-control studies; cohort studies; kidney neoplasms; prospective studies; vitamin D; RENAL-CELL CARCINOMA; VITAMIN-D STATUS; OCCUPATIONAL SUNLIGHT EXPOSURE; BREAST-CANCER; ULTRAVIOLET-B; MORTALITY; POPULATION; RADIATION; US;

D O I：

10.1093/aje/kwq115

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and kidney cancer within a large, nested case-control study developed as part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 775 kidney cancer cases and 775 age-, sex-, race-, and season-matched controls from 8 prospective cohort studies. Overall, neither low nor high concentrations of circulating 25(OH)D were significantly associated with kidney cancer risk. Although the data showed a statistically significant decreased risk for females (odds ratio = 0.31, 95% confidence interval: 0.12, 0.85) with 25(OH)D concentrations of >= 75 nmol/L, the linear trend was not statistically significant and the number of cases in this category was small (n = 14). The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically.

引用

页码：47 / 57

页数：11

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