Regioselective Functionalization of Chlorophthalazine Derivatives

被引：20

作者：

Crestey, Francois ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

SYNTHESIS-STUTTGART | 2010年 / 07期

基金：

欧洲研究理事会;

关键词：

chlorophthalazine derivatives; metalation; microwave irradiation; Negishi cross-coupling; zinc; BENZYLIC ZINC CHLORIDES; ORGANOZINC REAGENTS; DIRECT INSERTION; CROSS-COUPLINGS; LICL; MAGNESIUM; PALLADIUM; BROMIDES; HETEROAROMATICS; ARYLMAGNESIUM;

D O I：

10.1055/s-0029-1219231

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chlorophthalazines were efficiently metalated using tmpZnCl center dot LiCl under microwave irradiation. This provided novel substituted phthalazine derivatives after subsequent trapping of the resulting organometallic reagents with various electrophiles. Moreover, Negishi cross-coupling reactions have been performed affording new polyfunctionalized phthalazine scaffolds in very good yields.

引用

页码：1097 / 1106

页数：10

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