Parkin and Hsp70 sacked by BAG5

被引：22

作者：

Chung, KKK ^{[1
]}

Dawson, TM

机构：

[1] Johns Hopkins Univ, Sch Med, Inst Cell Engn, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

来源：

NEURON | 2004年 / 44卷 / 06期

关键词：

D O I：

10.1016/j.neuron.2004.12.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 ligase activity of parkin and the chaperone activity of Hsp70.

引用

页码：899 / 901

页数：3

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