CorreLogo: an online server for 3D sequence logos of RNA and DNA alignments

被引：22

作者：

Bindewald, Eckart

Schneider, Thomas D.

Shapiro, Bruce A. ^{[1
]}

机构：

[1] NCI Frederick, SAIC Frederick, Bas Res Program, Ft Detrick, MD 21702 USA

[2] NCI Frederick, Canc Res Ctr, Nanobiol Program, Ft Detrick, MD 21702 USA

来源：

NUCLEIC ACIDS RESEARCH | 2006年 / 34卷

关键词：

D O I：

10.1093/nar/gkl269

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present an online server that generates a 3D representation of properties of user- submitted RNA or DNA alignments. The visualized properties are information of single alignment columns, mutual information of two alignment positions as well as the position- specific fraction of gaps. The nucleotide composition of both single columns and column pairs is visualized with the help of color- coded 3D bars labeled with letters. The server generates both VRML and JVX output that can be viewed with a VRML viewer or the JavaView applet, respectively. We show that combining these different features of an alignment into one 3D representation is helpful in identifying correlations between bases and potential RNA and DNA base pairs. Significant known correlations between the tRNA 30 anticodon cardinal nucleotide and the extended anticodon were observed, as were correlations within the amino acid acceptor stem and between the cardinal nucleotide and the acceptor stem. The online server can be accessed using the URL http://correlogo.abcc.ncifcrf.gov.

引用

页码：W405 / W411

页数：7

共 37 条

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