Spirocycloisomerization of tethered alkylidene glycocyamidines: Synthesis of a base template common to the Palau'amine family of alkaloids

被引：69

作者：

Garrido-Hemandez, H ^{[1
]}

Nakadai, M ^{[1
]}

Vimolratana, M ^{[1
]}

Li, QY ^{[1
]}

Doundoulakis, T ^{[1
]}

Harran, PG ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 05期

关键词：

cyclization; guanidines; heterocycles; natural products; total synthesis;

D O I：

10.1002/anie.200462069

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The facile spirocyclization of tethered bisalkylidene 1 suggests a general synthetic strategy for preparing alkaloids of the palau'amine family. The development and characteristics of this core model system are discussed.

引用

页码：765 / 769

页数：5

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