Cloning and expression of an immunoglobulin superfamily gene (IGSF1) in Xq25

被引：36

作者：

Mazzarella, R

Pengue, G

Jones, J

Jones, C

Schlessinger, D

机构：

[1] Washington Univ, Sch Med, Ctr Med Genet, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA

来源：

GENOMICS | 1998年 / 48卷 / 02期

关键词：

D O I：

10.1006/geno.1997.5156

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have isolated a novel full-length cDNA for a gene (IGSFI) located in distal Xq25, This transcript is highly expressed in adult testis and fetal liver but is undetectable in adult liver, A smaller alternate form is highly expressed in adult heart, The gene encodes a protein of 1327 amino acids with several recognizable functional domains, The protein has a putative signal peptide and transmembrane region, 15 potential sites for N-linked glycosylation, and 12 Ca-type immunoglobulin (Ig)-like domains, All of the Ig-like domains contain the two conserved cysteine residues that form intradomain disulfide bonds typical of this superfamily, These features are consistent with a possible role for this molecule in cell surface recognition or cell-cell interaction. (C) 1998 Academic Press.

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页码：157 / 162

页数：6

相关论文

共 20 条

[11] HEAVY-CHAIN OF HUMAN HISTOCOMPATIBILITY ANTIGEN HLA-B7 CONTAINS AN IMMUNOGLOBULIN-LIKE REGION [J].

ORR, HT ;

LANCET, D ;

ROBB, RJ ;

LOPEZDECASTRO, JA ;

STROMINGER, JL .

NATURE, 1979, 282 (5736) :266-270

[12] Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome [J].

Pilia, G ;

HughesBenzie, RM ;

MacKenzie, A ;

Baybayan, P ;

Chen, EY ;

Huber, R ;

Neri, G ;

Cao, A ;

Forabosco, A ;

Schlessinger, D .

NATURE GENETICS, 1996, 12 (03) :241-247

[13] 4.5-Mb YAC STS contig at 50-kb resolution, spanning Xq25 deletions in two patients with lymphoproliferative syndrome [J].

Porta, G ;

MacMillan, S ;

Nagaraja, R ;

Mumm, S ;

Zucchi, I ;

Pilia, C ;

Maio, S ;

Featherstone, T ;

Schlessinger, D .

GENOME RESEARCH, 1997, 7 (01) :27-36

[14] UNIT-LENGTH LINE-1 TRANSCRIPTS IN HUMAN TERATOCARCINOMA CELLS [J].

SKOWRONSKI, J ;

FANNING, TG ;

SINGER, MF .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (04) :1385-1397

[15] DEFICIENT NATURAL-KILLER CELL-ACTIVITY IN X-LINKED LYMPHOPROLIFERATIVE SYNDROME [J].

SULLIVAN, JL ;

BYRON, KS ;

BREWSTER, FE ;

PURTILO, DT .

SCIENCE, 1980, 210 (4469) :543-545

[16] Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25 [J].

Wanschura, S ;

Schoenmakers, EFPM ;

Huysmans, C ;

Bartnitzke, S ;

vandeVen, WJM ;

Bullerdiek, J .

GENOMICS, 1996, 32 (02) :298-300

[17] COMPILATION OF PUBLISHED SIGNAL SEQUENCES [J].

WATSON, MEE .

NUCLEIC ACIDS RESEARCH, 1984, 12 (13) :5145-5164

[18] THE IMMUNOGLOBULIN SUPERFAMILY - DOMAINS FOR CELL-SURFACE RECOGNITION [J].

WILLIAMS, AF ;

BARCLAY, AN .

ANNUAL REVIEW OF IMMUNOLOGY, 1988, 6 :381-405

[19] SURFACE MOLECULES AND CELL-INTERACTIONS [J].

WILLIAMS, AF .

JOURNAL OF THEORETICAL BIOLOGY, 1982, 98 (02) :221-234

[20] NEURONAL CELL THY-1 GLYCOPROTEIN - HOMOLOGY WITH IMMUNOGLOBULIN [J].

WILLIAMS, AF ;

GAGNON, J .

SCIENCE, 1982, 216 (4547) :696-703