Optical fiber affinity biosensor based on localized surface plasmon resonance

被引：159

作者：

Mitsui, K

Handa, Y

Kajikawa, K ^{[1
]}

机构：

[1] Tokyo Inst Technol, Interdisciplinary Grad Sch Sci & Engn, Midori Ku, Yokohama, Kanagawa 2268502, Japan

[2] JST, PRESTO, Kawaguchi, Saitama, Japan

来源：

APPLIED PHYSICS LETTERS | 2004年 / 85卷 / 18期

关键词：

D O I：

10.1063/1.1812583

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

A highly sensitive micrometer-sized optical fiber affinity biosensor is reported based on the localized surface plasmon resonance in gold nanoparticles adsorbed at an endface of an optical fiber. This sensor probes the affinity between biological molecules in real time without any labeling of the analyte. The highest resolution of 10(-5) in refractive index units is demonstrated with a red-light-emitting diode used as a light source. This value corresponds to an adsorption amount of 10(-12) g/mm(2) in the case of the affinity measurement. This sensitivity is similar to that of the conventional surface plasmon resonance biosensors that use attenuated total reflection optics. (C) 2004 American Institute of Physics.

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收藏

页码：4231 / 4233

页数：3

相关论文

共 9 条

[1] Colloidal gold-modified optical fiber for chemical and biochemical sensing [J].

Cheng, SF ;

Chau, LK .

ANALYTICAL CHEMISTRY, 2003, 75 (01) :16-21

[2] Cap-shaped gold nanoparticles for an optical biosensor [J].

Himmelhaus, M ;

Takei, H .

SENSORS AND ACTUATORS B-CHEMICAL, 2000, 63 (1-2) :24-30

[3] Nanosphere lithography: Effect of the external dielectric medium on the surface plasmon resonance spectrum of a periodic array of sliver nanoparticles [J].

Jensen, TR ;

Duval, ML ;

Kelly, KL ;

Lazarides, AA ;

Schatz, GC ;

Van Duyne, RP .

JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (45) :9846-9853

[4] Interfaces and thin films as seen by bound electromagnetic waves [J].

Knoll, W .

ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 1998, 49 :569-638

[5] CALCULATION OF TOTAL CROSS-SECTIONS OF MULTIPLE-SPHERE CLUSTERS [J].

MACKOWSKI, DW .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION, 1994, 11 (11) :2851-2861

[6] A colorimetric gold nanoparticle sensor to interrogate biomolecular interactions in real time on a surface [J].

Nath, N ;

Chilkoti, A .

ANALYTICAL CHEMISTRY, 2002, 74 (03) :504-509

[7] Local plasmon sensor with gold colloid monolayers deposited upon glass substrates [J].

Okamoto, T ;

Yamaguchi, I ;

Kobayashi, T .

OPTICS LETTERS, 2000, 25 (06) :372-374

[8] Solvent refractive index and core charge influences on the surface plasmon absorbance of alkanethiolate monolayer-protected gold clusters [J].

Templeton, AC ;

Pietron, JJ ;

Murray, RW ;

Mulvaney, P .

JOURNAL OF PHYSICAL CHEMISTRY B, 2000, 104 (03) :564-570

[9] EFFECT OF THE SOLUTION REFRACTIVE-INDEX ON THE COLOR OF GOLD COLLOIDS [J].

UNDERWOOD, S ;

MULVANEY, P .

LANGMUIR, 1994, 10 (10) :3427-3430