Cap-shaped gold nanoparticles for an optical biosensor

被引：175

作者：

Himmelhaus, M ^{[1
]}

Takei, H ^{[1
]}

机构：

[1] Hitachi Ltd, Cent Res Lab, Hatoyama, Saitama 3500395, Japan

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2000年 / 63卷 / 1-2期

关键词：

polystyrene latex spheres; gold clusters; optical biosensor; alkanethiols; biotin/avidin binding;

D O I：

10.1016/S0925-4005(99)00393-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Cap-shaped Au nanoparticles have been formed by evaporating An on a dense monolayer of randomly adsorbed monodisperse polystyrene (PS) spheres with a diameter of 110 nm. The resulting sample exhibits a large extinction coefficient of optical density of 2.4 with a bandwidth of 100 nm in the visible region. The extinction peak position is found to depend linearly on the refractive index of the environment. As demonstrated by successful detection of octadecanethiolate monolayer formation as well as biotin/avidin binding, the sub-monolayer sensitivity of the simple novel device reported here promises development of inexpensive optical biosensors for massively parallel detection. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：24 / 30

页数：7

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