Brain MRI with laser-polarized Xe-129

被引：135

作者：

Swanson, SD

Rosen, MS

Agranoff, BW

Coulter, KP

Welsh, RC

Chupp, TE

机构：

[1] UNIV MICHIGAN,DEPT PHYS,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,NEUROSCI LAB,ANN ARBOR,MI 48109

来源：

MAGNETIC RESONANCE IN MEDICINE | 1997年 / 38卷 / 05期

关键词：

MRI; xenon; brain imaging; laser polarization;

D O I：

10.1002/mrm.1910380503

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The feasibility of brain MRI with laser-polarized Xe-129 in a small animal model is demonstrated. Naturally abundant Xe-129 is polarized and introduced into the lungs of Sprague-Dawley rats. Polarized xenon gas dissolves in the blood and is transported to the brain where it accumulates in brain tissue. Spectroscopic studies reveal a single, dominant, tissue-phase NMR resonance in the head at 194.5 ppm relative to the gas phase resonance. Images of Xe-129 in the rat head were obtained with 98-mu l voxels by 2D chemical shift imaging and show that xenon is localized to the brain. This work establishes that nuclear polarization produced in the gas phases survives transport to the brain where it may be imaged. Increases in polarization and delivered volume of Xe-129 will allow clinical measurements of regional cerebral blood flow.

引用

页码：695 / 698

页数：4

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