Bioactive Metabolites from the Sponge-Derived Fungus Aspergillus versicolor

被引：344

作者：

Lee, Yoon Mi ^{[1
]}

Li, Huayue ^{[1
]}

Hong, Jongki ^{[2
]}

Cho, Hee Young ^{[3
]}

Bae, Kyung Sook ^{[4
]}

Kim, Mi Ae ^{[1
]}

Kim, Dong-Kyoo ^{[5
,6
]}

Jung, Jee H. ^{[1
]}

机构：

[1] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

[2] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

[3] Korea Res Inst Chem Technol, Taejon 305343, South Korea

[4] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea

[5] Inje Univ, Dept Biomed Chem, Gimhae 621749, South Korea

[6] Inje Univ, Inst Funct Mat, Gimhae 621749, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2010年 / 33卷 / 02期

关键词：

Aspergillus versicolor; Cytotoxicity; Antibacterial activity; Polyketide; Xanthone; Anthraquinone; ENDOPHYTIC FUNGUS; MARINE; IDENTIFICATION; PATHWAY; ESTERS;

D O I：

10.1007/s12272-010-0207-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As part of an ongoing search for bioactive metabolites from the fungus Aspergillus versicolor derived from a marine sponge Petrosia sp., an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4-8) were isolated by bioactivity-guided fractionation. The gross structures were determined based on the NMR and MS spectroscopic data, and the absolute configurations were defined by comparison of optical rotation data with those of reported. Compounds 2, 4, 5, and 7 exhibited significant cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with IC50 values in the range of 0.41-4.61 mu g/mL. Compounds 4 and 7 exhibited antibacterial activity against several clinically isolated Gram-positive strains with MIC values of 0.78-6.25 mu g/mL.

引用

页码：231 / 235

页数：5

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