Asymmetric addition of dialkyl phosphite and diamido phosphite anions to chiral, enantiopure sulfinimines:: a new, convenient route to enantiomeric α-aminophosphonic acids

被引：68

作者：

Mikolajczyk, M ^{[1
]}

Lyzwa, P ^{[1
]}

Drabowicz, J ^{[1
]}

机构：

[1] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Organ Sulfur Cpds, PL-90363 Lodz, Poland

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(97)00606-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Lithium or sodium dialkyl phosphites and diamido phosphites 3 undergo addition to (+)-(S)-benzylidene-p-toluenesulfinamide 2 affording N-sulfinyl-alpha-aminophosphonates 4 in a diastereoisomeric ratio from 63:37 to 94:6. The major diastereoisomers formed in addition of lithium dimethyl phosphite 3a and lithium bis-diethylamido phosphite 3e to (+)-(S)-2 were separated and converted into enantiopure (+)-(R)- and (-)-(S)-alpha-aminobenzyl phosphonic acids 5, respectively. (C) 1997 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3991 / 3994

页数：4

共 12 条

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