Proteomics as a probe of microbial pathogenesis and its molecular boundaries

被引：20

作者：

Bhavsar, Amit P. ^{[1
]}

Auweter, Sigrid D. ^{[1
]}

Finlay, B. Brett ^{[1
]}

机构：

[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

来源：

FUTURE MICROBIOLOGY | 2010年 / 5卷 / 02期

关键词：

bacterial pathogenesis; host-pathogen interface; proteomics; secretome; T3SS; virulence factor; ENTEROPATHOGENIC ESCHERICHIA-COLI; III SECRETION SYSTEM; PHOSPHOTHREONINE LYASE ACTIVITY; RAW; 264.7; MACROPHAGES; PYLORI CAGA PROTEIN; PSEUDOMONAS-SYRINGAE; HELICOBACTER-PYLORI; MYCOBACTERIUM-TUBERCULOSIS; NEISSERIA-MENINGITIDIS; QUANTITATIVE-ANALYSIS;

D O I：

10.2217/FMB.09.114

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Proteomic technology offers an unprecedented systematic approach to investigate the protein complement of any organism. The field of microbial pathogenesis has greatly benefited from other systems approaches, and the application of proteomics to the study of infectious agents is beginning to emerge. Such applications include unambiguously identifying complete virulence factor inventories, studying the response of both host and pathogen to the infection process and elucidating mechanistic actions of virulence factors as they interface with host cells. This review will highlight examples where proteomic studies have contributed to our understanding of pathogenesis in these areas, with an emphasis on pathogens that employ type III and type IV secretion systems. In addition, we will discuss areas where proteomics may help shape further investigation and discovery in this field.

引用

页码：253 / 265

页数：13

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