[GRAPHICS] A catalysis-based approach to the core region 24 of the antitumor agents salicylihalamides A and B is reported. Key steps are two asymmetric hydrogenations of beta -keto esters 13 and 16 catalyzed by [(R)-BINAP-RuCl2](2). NEt3 and an RCM-based macrocyclization effected by the NHC-containing ruthenium carbene 21. The stereochemical outcome of the tatter reaction is controlled by remote substituents on the phenolic OH group of the cyclization precursor 23.
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Chang, S
Jones, L
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Jones, L
Wang, CM
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Wang, CM
Henling, LM
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Henling, LM
Grubbs, RH
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Chatterjee, AK
Grubbs, RH
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
DEVOS, A
REMION, J
论文数: 0引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
REMION, J
FRISQUEHESBAIN, AM
论文数: 0引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
FRISQUEHESBAIN, AM
COLENS, A
论文数: 0引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
COLENS, A
GHOSEZ, L
论文数: 0引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
机构:
NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USANCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA
Erickson, KL
Beutler, JA
论文数: 0引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USANCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA
Beutler, JA
Cardellina, JH
论文数: 0引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USANCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA
Cardellina, JH
Boyd, MR
论文数: 0引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USANCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Chang, S
Jones, L
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Jones, L
Wang, CM
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Wang, CM
Henling, LM
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Henling, LM
Grubbs, RH
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
Chatterjee, AK
Grubbs, RH
论文数: 0引用数: 0
h-index: 0
机构:
CALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USACALTECH, Arnold & Mabel Beckman Labs Chem Synthesis, Div Chem & Chem Engn, Pasadena, CA 91125 USA
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
DEVOS, A
REMION, J
论文数: 0引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
REMION, J
FRISQUEHESBAIN, AM
论文数: 0引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
FRISQUEHESBAIN, AM
COLENS, A
论文数: 0引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
COLENS, A
GHOSEZ, L
论文数: 0引用数: 0
h-index: 0
机构:
CATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUMCATHOLIC UNIV LOUVAIN,CHIM ORGAN SYNTHESE LAB,B-1348 LOUVAIN LA NEUVE,BELGIUM
机构:
NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USANCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA
Erickson, KL
Beutler, JA
论文数: 0引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USANCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA
Beutler, JA
Cardellina, JH
论文数: 0引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USANCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA
Cardellina, JH
Boyd, MR
论文数: 0引用数: 0
h-index: 0
机构:
NCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USANCI, FREDERICK CANC RES & DEV CTR, LAB DRUG DISCOVERY RES & DEV, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA