Applications of transketolases in organic synthesis

被引：96

作者：

Turner, NJ ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(00)00140-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enzyme transketolase has been employed as a catalyst for asymmetric carbon-carbon bond formation in the synthesis of biologically important molecules. A number of important parameters have been addressed including substrate specificity, over-expression of the protein in suitable host systems, scale-up of the reaction and use of transketolase in multi-enzyme experiments. X-ray structural studies have been used to probe the origin of the asymmetry of the carbon-carbon bond-forming process.

引用

页码：527 / 531

页数：5

共 31 条

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