Opinion -: Therapeutic vaccines against HIV need international partnerships

被引：29

作者：

Autran, B ^{[1
]}

Debré, P

Walker, B

Katlama, C

机构：

[1] CHU Pitie Salpetriere, Lab Immunol Cellulaire, Serv Malad Infect, F-75651 Paris, France

[2] Massachusetts Gen Hosp, Partners AIDS Res Ctr, Howard Hughes Med Inst, Boston, MA 02129 USA

[3] Harvard Univ, Sch Med, Div AIDS, Boston, MA 02129 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1038/nri1107

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The successes of anti-retroviral treatments against HIV are limited today by the cost and toxicity of lifelong administration. An innovative therapeutic strategy has been proposed to boost the immune system of infected patients with HIV vaccines and to help limit the use of anti-retroviral treatments. This perspective article reviews the crucial questions raised by such a strategy and the main international efforts that are already set up to provide rapid answers - in particular, a not-for-profit international network that is dedicated to the development of therapeutic immunization programmes against HIV.

引用

页码：503 / 508

页数：6

共 39 条

[1] HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus [J].

Altfeld, M ;

Allen, TM ;

Yu, XG ;

Johnston, MN ;

Agrawal, D ;

Korber, BT ;

Montefiori, DC ;

O'Connor, DH ;

Davis, BT ;

Lee, PK ;

Maier, EL ;

Harlow, J ;

Goulder, PJR ;

Brander, C ;

Rosenberg, ES ;

Walker, BD .

NATURE, 2002, 420 (6914) :434-439

[2] Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection [J].

Altfeld, M ;

Rosenberg, ES ;

Shankarappa, R ;

Mukherjee, JS ;

Hecht, FM ;

Eldridge, RL ;

Addo, MM ;

Poon, SH ;

Phillips, MN ;

Robbins, GK ;

Sax, PE ;

Boswell, S ;

Kahn, JO ;

Brander, C ;

Goulder, PJR ;

Levy, JA ;

Mullins, JI ;

Walker, BD .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (02) :169-180

[3] Positive effects of combined antiretroviral therapy on CD4(+) T cell homeostasis and function in advanced HIV disease [J].

Autran, B ;

Carcelain, G ;

Li, TS ;

Blanc, C ;

Mathez, D ;

Tubiana, R ;

Katlama, C ;

Debre, P ;

Leibowitch, J .

SCIENCE, 1997, 277 (5322) :112-116

[4]

AUTRAN B, 2000, SCIENCE, V104, pR13

[5] Immunotherapy for AIDS virus infections: Cautious optimism for cell-based vaccine [J].

Bhardwaj, N ;

Walker, BD .

NATURE MEDICINE, 2003, 9 (01) :13-14

[6] Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy [J].

Brinkman, K ;

Smeitink, JA ;

Romijn, JA ;

Reiss, P .

LANCET, 1999, 354 (9184) :1112-1115

[7] Transient mobilization of human immunodeficiency virus (HIV)-specific CD4 T-helper cells fails to control virus rebounds during intermittent antiretroviral therapy in chronic HIV type 1 infection [J].

Carcelain, G ;

Tubiana, R ;

Samri, A ;

Calvez, V ;

Delaugerre, C ;

Agut, H ;

Katlama, C ;

Autran, B .

JOURNAL OF VIROLOGY, 2001, 75 (01) :234-241

[8] A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors [J].

Carr, A ;

Samaras, K ;

Burton, S ;

Law, M ;

Freund, J ;

Chisholm, DJ ;

Cooper, DA .

AIDS, 1998, 12 (07) :F51-F58

[9] HIV preferentially infects HIV-specific CD4+ T cells [J].

Douek, DC ;

Brenchley, JM ;

Betts, MR ;

Ambrozak, DR ;

Hill, BJ ;

Okamoto, Y ;

Casazza, JP ;

Kuruppu, J ;

Kuntsman, K ;

Wolinsky, S ;

Grossman, Z ;

Dybul, M ;

Oxenius, A ;

Price, DA ;

Connors, M ;

Koup, RA .

NATURE, 2002, 417 (6884) :95-98

[10]

DOVE A, 1999, NAT MED, V1, P5

← 1 2 3 4 →