The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase

被引：86

作者：

Eissenberg, Joel C.

Lee, Min Gyu

Schneider, Jessica

Ilvarsonn, Anne

Shiekhattar, Ramin

Shilatifard, Ali

机构：

[1] St Louis Univ, Sch Med, Edward A Doisy Dept Biochem & Mol Biol, St Louis, MO 63104 USA

[2] St Louis Univ, Sch Med, Ctr Canc, St Louis, MO 63104 USA

[3] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

[4] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 04期

关键词：

MOLECULAR REGULATION; METHYLATION; EXPRESSION; LYSINE-4; COMPASS; PROTEIN; CHROMODOMAINS; HOMOLOG; YEAST; ASH1;

D O I：

10.1038/nsmb1217

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone H3 Lys4 (H3K4) is methylated by yeast Set1-COMPASS and its mammalian homolog, the MLL complex. Human JARID1d can demethylate trimethyl-H3K4 (H3K4me3). We identified Drosophila melanogaster little imaginal discs (Lid) as the JARID1d homolog. We report that Lid knockdown using RNA interference results in a specific genome-wide increase in H3K4me3 levels without affecting other patterns of H3 methylation, and results in an altered distribution of the chromo-helicase protein Chd1.

引用

页码：344 / 346

页数：3

共 18 条

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