A flexible cold microplasma jet using biocompatible dielectric tubes for cancer therapy

被引：92

作者：

Kim, Jae Young ^{[1
]}

Kim, Sung-O ^{[1
]}

Wei, Yanzhang ^{[2
]}

Li, Jinhua ^{[2
]}

机构：

[1] Clemson Univ, Holcombe Dept Elect & Comp Engn, Ctr Opt Mat Sci & Engn Technol, Clemson, SC 29634 USA

[2] Clemson Univ, Dept Biol Sci, Inst Biomed, Greenville, SC 29605 USA

来源：

APPLIED PHYSICS LETTERS | 2010年 / 96卷 / 20期

关键词：

biomedical materials; cancer; cellular biophysics; dielectric devices; plasma applications; plasma jets; tumours; PLASMA;

D O I：

10.1063/1.3431392

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

This paper describes a flexible microplasma jet device using a Tygon (R) S-54-HL tube as a biocompatible tube and its potential in developing cancer therapies. The optical and physical properties of the plasma jets and preliminary apoptosis data of cultured murine tumor cells and nontumor fibroblast cells treated with these plasma jets are presented. Microplasma jets were observed to induce apoptosis in cultured murine cells in a dose-dependent manner. The murine melanoma tumor cells were more sensitive to plasma treatment than fibroblast cells. These features allow the direct and precise application of this microplasma jet device to tumor cells. (C) 2010 American Institute of Physics. [doi:10.1063/1.3431392]

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