Air plasma coupled with antibody-conjugated nanoparticles: a new weapon against cancer

被引：160

作者：

Kim, G. C. ^{[1
]}

Kim, G. J. ^{[2
]}

Park, S. R. ^{[1
]}

Jeon, S. M. ^{[3
]}

Seo, H. J. ^{[3
]}

Iza, F. ^{[4
]}

Lee, J. K. ^{[2
]}

机构：

[1] Pusan Natl Univ, Sch Dent, Dept Oral Anat & Cell Biol, Pusan 602739, South Korea

[2] Pohang Univ Sci & Technol, Dept Elect & Elect Engn, Pohang 790784, South Korea

[3] Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 790784, South Korea

[4] Loughborough Univ Technol, Dept Elect & Elect Engn, Loughborough LE11 3TU, Leics, England

来源：

JOURNAL OF PHYSICS D-APPLIED PHYSICS | 2009年 / 42卷 / 03期

关键词：

FOCAL-ADHESION KINASE; GOLD NANOPARTICLES; GROWTH-FACTOR;

D O I：

10.1088/0022-3727/42/3/032005

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Ambient air plasmas have been known to kill cancer cells. To enhance selectivity we have used antibody-conjugated nanoparticles. We achieved five times enhancement of melanoma cell death over the case of the plasma alone by using an air plasma with gold nanoparticles bound to anti-FAK antibodies. Our results show that this new interdisciplinary technique has enormous potential for use as a complement to conventional therapies.

引用

页数：5

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