IP3 receptors in cell survival and apoptosis:: Ca2+ release and beyond

被引：135

作者：

Joseph, Suresh K. ^{[1
]}

Hajnoczky, Gyorgy ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Pathol & Cell Biol, Philadelphia, PA 19107 USA

来源：

APOPTOSIS | 2007年 / 12卷 / 05期

关键词：

apoptosis; calcium; endoplasmic reticulum; IP3; receptor; mitochondria;

D O I：

10.1007/s10495-007-0719-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) serve to discharge Ca2+ from ER stores in response to agonist stimulation. The present review summarizes the role of these receptors in models of Ca2+-dependent apoptosis. In particular we focus on the regulation of IP(3)Rs by caspase-3 cleavage, cytochrome c, anti-apoptotic proteins and Akt kinase. We also address the evidence that some of the effects of IP(3)Rs in apoptosis may be independent of their ion-channel function. The role of IP(3)Rs in delivering Ca2+ to the mitochondria is discussed from the perspective of the factors determining inter-organellar dynamics and the spatial proximity of mitochondria and ER membranes.

引用

页码：951 / 968

页数：18

共 170 条

[1] Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria [J].

Arnaudeau, S ;

Frieden, M ;

Nakamura, K ;

Castelbou, C ;

Michalak, M ;

Demaurex, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (48) :46696-46705

[2] Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis [J].

Assefa, Z ;

Bultynck, G ;

Szlufcik, K ;

Kasri, NN ;

Vermassen, E ;

Goris, J ;

Missiaen, L ;

Callewaert, G ;

Parys, JB ;

De Smedt, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (41) :43227-43236

[3]

BAFFY G, 1993, J BIOL CHEM, V268, P6511

[4] Inositol 1,4,5-trisphosphate receptor type 1 phosphorylation and regulation by extracellular signal-regulated kinase [J].

Bai, Gui-Rong ;

Yang, Ling-Hai ;

Huang, Xiu-Ying ;

Sun, Fang-Zhen .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2006, 348 (04) :1319-1327

[5] Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity [J].

Bano, D ;

Young, KW ;

Guerin, CJ ;

LeFeuvre, R ;

Rothwell, NJ ;

Naldini, L ;

Rizzuto, R ;

Carafoli, E ;

Nicotera, P .

CELL, 2005, 120 (02) :275-285

[6] Cardiac type 2 inositol 1,4,5-trisphosphate receptor - Interaction and modulation by calcium/calmodulin-dependent protein kinase II [J].

Bare, DJ ;

Kettlun, CS ;

Liang, M ;

Bers, DM ;

Mignery, GA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (16) :15912-15920

[7] Bcl-2 overexpression prevents calcium overload and subsequent apoptosis in dystrophic myotubes [J].

Basset, O ;

Boittin, FX ;

Cognard, C ;

Constantin, B ;

Ruegg, UT .

BIOCHEMICAL JOURNAL, 2006, 395 :267-276

[8] Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis [J].

Bassik, MC ;

Scorrano, L ;

Oakes, SA ;

Pozzan, T ;

Korsmeyer, SJ .

EMBO JOURNAL, 2004, 23 (05) :1207-1216

[9] Cytochrome c binds to inositol (1,4,5) trisphosphate and ryanodine receptors in vivo after transient brain ischemia in gerbils [J].

Beresewicz, M ;

Kowalczyk, JE ;

Zablocka, B .

NEUROCHEMISTRY INTERNATIONAL, 2006, 48 (6-7) :568-571

[10] BELL-SHAPED CALCIUM-RESPONSE CURVES OF INS(1,4,5)P3-GATED AND CALCIUM-GATED CHANNELS FROM ENDOPLASMIC-RETICULUM OF CEREBELLUM [J].

BEZPROZVANNY, I ;

WATRAS, J ;

EHRLICH, BE .

NATURE, 1991, 351 (6329) :751-754

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