Inhibitory effect of interleukin-1α-induced apoptosis by Polygala tenuifolia in Hep G2 cells

被引：10

作者：

Koo, HN

Jeong, HJ

Kim, KR

Kim, JC

Kim, KS

Kang, BK

Kim, HM

Kim, JJ ^{[1
]}

机构：

[1] Wonkwang Univ, Sch Med, Dept Anat, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, Ctr Oriental Med Sci, Iksan 570749, Chonbuk, South Korea

[3] Wonkwang Univ, Coll Pharm, Dept Oriental Pharm, Iksan 570749, Chonbuk, South Korea

[4] Wonkwang Univ, Coll Oriental Med, Dept Internal Med, Iksan 570749, Chonbuk, South Korea

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 2000年 / 22卷 / 03期

关键词：

D O I：

10.3109/08923970009026010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A human hepatoma cell line, Hep G2 cells are reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Polygala tenuifolia (WILLDENOW) (Polygalaceae) roots (PTAE) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. PTAE (0.01-1 mu g/ml) dose-dependently inhibited the EtOH-induced interluekin-1 alpha (IL-1 alpha) secretion. PTAE (0.01-1 mu g/ml) also inhibited the EtOH- and IL-1 alpha-induced cytotoxicity. Furthermore, we found that PTAE inhibited the IL-1 alpha-induced apoptosis of Hep G2 cells. These results suggest that PTAE may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells.

引用

页码：531 / 544

页数：14

共 25 条

[11] CIRCULATING TUMOR-NECROSIS-FACTOR, INTERLEUKIN-1 AND INTERLEUKIN-6 CONCENTRATIONS IN CHRONIC-ALCOHOLIC PATIENTS [J].