Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention

被引:58
作者
Littman, A. J.
Vitiello, M. V.
Foster-Schubert, K.
Ulrich, C. M.
Tworoger, S. S.
Potter, J. D.
Weigle, D. S.
McTiernan, A.
机构
[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
[2] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[3] Univ Washington, Dept Psychiat & Behav Sci, Sch Med, Seattle, WA 98104 USA
[4] Univ Washington, Sch Med, Dept Med, Div Med Endocrinol & Nutr, Seattle, WA 98195 USA
[5] VA Puget Sound Hlth Care Syst, Seattle, WA USA
[6] Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA
[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[8] Univ Washington, Harborview Med Ctr, Div Endocrinol, Seattle, WA 98104 USA
关键词
physical activity; randomized trial; ghrelin; leptin; sleep; weight change;
D O I
10.1038/sj.ijo.0803438
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To investigate cross-sectional and longitudinal relationships among exercise, sleep, ghrelin and leptin. Methods: We randomly assigned 173 post-menopausal sedentary overweight ( body mass index >= 24.0 kg/m(2) and > 33% body fat) women aged 50-75 years living in western Washington State to either a facility- and home-based moderate-intensity physical activity intervention or a stretching control group. Fasting plasma ghrelin, leptin, measured height, weight and self-reported sleep were assessed at baseline and 12 months. Results: There were no consistent cross-sectional patterns between self-reported sleep measures and ghrelin or leptin at baseline. The weight loss differences between exercisers and stretchers were greater for those who slept less at follow-up than at baseline compared to those whose sleep duration did not change (-3.2 kg, 95% confidence interval (CI) -5.8, -0.5). Improvements in sleep quality were associated with significantly greater differences between exercisers and stretchers for ghrelin increases ( improved vs same sleep quality: +115 pg/ml, 95% CI +25, +206) and leptin decreases ( improved vs worsened sleep quality: -5.7 ng/ml, 95% CI -9.5, -1.5). Conclusion: There was only limited evidence that changes in sleep duration or quality modified exercise-induced changes in weight, ghrelin or leptin. Moreover, the observed differences were not in the directions hypothesized. Future longitudinal studies including population-based samples using objective measures of sleep and long follow-up may help to clarify these relationships.
引用
收藏
页码:466 / 475
页数:10
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