Synthesis of 2-oxazolines mediated by N,N′-diisopropylcarbodiimide

被引：31

作者：

Crosignani, S ^{[1
]}

Young, AC ^{[1
]}

Linclau, B ^{[1
]}

机构：

[1] Univ Southampton, Sch Chem, Combinatorial Ctr Excellence, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 52期

关键词：

2-oxazoline; isourea; Lewis acid; microwave irradiation; carbodiimide;

D O I：

10.1016/j.tetlet.2004.10.143

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-(beta-Hydroxy)amides can be cyclised by reaction with diisopropy1carbodiimide (DIC) to give the corresponding 2-oxazolines in high yields. The reaction requires only very mild Lewis-acid catalysis (5mol% Cu(OTf)(2)) and can be accomplished with simple heating, or in very short reaction times under microwave irradiation. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：9611 / 9615

页数：5

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