Tropheryma whipplei in Patients with Pneumonia

被引：87

作者：

Bousbia, Sabri ^{[1
]}

Papazian, Laurent ^{[1
,2
]}

Auffray, Jean-Pierre ^{[2
]}

Fenollar, Florence ^{[1
]}

Martin, Claude ^{[3
]}

Li, Wenjun ^{[1
]}

Chiche, Laurent ^{[2
]}

La Scola, Bernard ^{[1
]}

Raoult, Didier ^{[1
]}

机构：

[1] Fac Med Marseille, CNRS, IRD, F-13385 Marseille, France

[2] Hop Sud, Marseille, France

[3] Hop Nord Marseille, Marseille, France

来源：

EMERGING INFECTIOUS DISEASES | 2010年 / 16卷 / 02期

关键词：

VENTILATOR-ASSOCIATED PNEUMONIA; CYSTIC-FIBROSIS; WHIPPELII DNA; DISEASE; GENOME; IDENTIFICATION; BACILLUS; BACTERIUM; CULTURE; SALIVA;

D O I：

10.3201/eid1602.090610

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tropheryma whipplei is the etiologic pathogenic agent of Whipple disease (WD), characterized by various clinical signs, such as diarrhea, weight loss, lymphadenopathy, and polyarthritis. PCR-based methods for diagnosis of WD have been developed. T whipplei has been identified in saliva and stool samples from patients with WD and from healthy persons. T whipplei DNA has also been found in bronchoalveolar lavage (BAL) samples of a child with pneumonia. We detected DNA of T whipplei in 6 (3%) of 210 BAL samples collected in intensive care units by using 16S rDNA and specific quantitative PCR. We identified 4 novel genotypes of T whipplei. In 1 case, T whipplei was the only bacterium; in 4 others, it was associated with buccal flora. We suggest that T whipplei should be investigated as an etiologic agent of pneumonia.

引用

页码：258 / 263

页数：6

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