An evolutionary basis for scrapie disease:: identification of a fish prion mRNA

被引：54

作者：

Rivera-Milla, E ^{[1
]}

Stuermer, CAO ^{[1
]}

Málaga-Trillo, E ^{[1
]}

机构：

[1] Univ Konstanz, Dept Biol, D-78457 Constance, Germany

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 02期

关键词：

D O I：

10.1016/S0168-9525(02)00032-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Infectious prion proteins cause neurodegenerative disease in mammals owing to the acquisition of an aberrant conformation. We cloned a Fugu rubripes gene that encodes a structurally conserved prion protein, and found rapid rates of molecular divergence among prions from different vertebrate classes, along with molecular stasis within each class. We propose that a directional trend in the evolution of prion sequence motifs associated with pathogenesis and infectivity could account for the origin of scrapie in mammals.

引用

页码：72 / 75

页数：4

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