MicroRNAs and hematopoietic differentiation

被引：14

作者：

Fatica, A. ^{[1
]}

Rosa, A.

Fazi, F.

Ballarino, M.

Morlando, M.

De Angelis, F. G.

Caffarelli, E.

Nervi, C.

Bozzoni, I.

机构：

[1] Univ Roma La Sapienza, Inst Pasteur Cenci Bolognetti, Dept Genet & Mol Biol, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, IBPM, I-00185 Rome, Italy

[3] Univ Roma La Sapienza, Dept Histol & Med Embryol, I-00185 Rome, Italy

来源：

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY | 2006年 / 71卷

关键词：

D O I：

10.1101/sqb.2006.71.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of microRNAs (miRNAs) and of their mechanism of action has provided some very new clues on how gene expression is regulated. These studies established new concepts on how posttranscriptional control can fine-tune gene expression during differentiation and allowed the identification of new regulatory circuitries as well as factors involved therein. Because of the wealth of information available about the transcriptional and cellular networks involved in hematopoietic differentiation, the hematopoietic system is ideal for studying cell lineage specification. An interesting interplay between miRNAs and lineage-specific transcriptional factors has been found, and this can help us to understand how terminal differentiation is accomplished.

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收藏

页码：205 / 210

页数：6

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