Ligand-5-HT1A receptor interaction

被引：4

作者：

Chilmonczyk, Z ^{[1
]}

机构：

[1] Pharmaceut Res Inst, PL-01793 Warsaw, Poland

来源：

FARMACO | 2000年 / 55卷 / 03期

关键词：

5-HT1A receptor ligands; pharmacophore model; intrinsic activity;

D O I：

10.1016/S0014-827X(00)00019-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present paper the general structure and pharmacophore of some 5-HT1A receptor ligands are described, For several compounds (similar to 15)the intrinsic activity in lower lip retraction (postsynaptic, rat) and hypothermia (presynaptic, mice) tests was determined. For the identified functional presynaptic agonists and antagonists the influence on the brain serotonin level was examined. No direct correlation between the functional intrinsic activity and the influence on the level was observed. Molecular modelling revealed the possibility of the existence of different binding sites for different examined compounds. (C) 2000 Elsevier Science S.A. All rights reserved.

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页码：191 / 193

页数：3

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