Mitochondrial proteomics in free radical research

被引:54
作者
Bailey, SM
Landar, A
Darley-Usmar, V
机构
[1] Univ Alabama, Sch Publ Hlth, Dept Environm Hlth Sci, Birmingham, AL 35294 USA
[2] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA
基金
美国国家卫生研究院;
关键词
mitochondria; proteomics; posttranslational modifications; free radical; oxidative and nitrosative stress; blue native gel electrophoresis; alcohol;
D O I
10.1016/j.freeradbiomed.2004.10.011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The importance of mitochondrial dysfunction in numerous diseases has long been appreciated. The impact of oxidative and nitrosative stress on mitochondrial function is complex; however, recent progress in the field using proteomics technologies has begun to shed light on the molecular defects responsible for mitochondrial and cellular dysfunction. This review focuses on the state-of-the-art technologies being used and current research endeavors in the field of mitochondrial proteomics with emphasis on those advancements being made in the field of free radical biology to identify the importance of alterations to the mitochondrial proteome in the development of disease. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:175 / 188
页数:14
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