Array-Based Sensing of Normal, Cancerous, and Metastatic Cells Using Conjugated Fluorescent Polymers

被引：132

作者：

Bajaj, Avinash ^{[2
]}

Miranda, Oscar R. ^{[2
]}

Phillips, Ronnie ^{[1
]}

Kim, Ik-Bum ^{[1
]}

Jerry, D. Joseph ^{[3
]}

Bunz, Uwe H. F. ^{[1
]}

Rotello, Vincent M. ^{[2
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

[2] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

[3] Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 03期

关键词：

SENSOR ARRAY; COLORIMETRIC IDENTIFICATION; NANOPARTICLE; PROTEINS; DISCRIMINATION; IONS; PPE;

D O I：

10.1021/ja9061272

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A family of conjugated fluorescent polymers was used to create an array for cell sensing. Fluorescent conjugated polymers with pendant charged residues provided multivalent interactions with cell membranes, allowing the detection of subtle differences between different cell types on the basis of cell surface features. Highly reproducible characteristic patterns were obtained from different cell types as well as from isogenic cell lines, enabling the identification of the cell type as well differentiating between normal, cancerous, and metastatic isogenic cell types with high accuracy.

引用

页码：1018 / 1022

页数：5

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